Panama City to Santo Domingo

1 ways to travelfastest 4h 02mfly from €224
Photo: Michelen Studios / Unsplash

How the cheapest fare moved

Jul 30: €254 €254 Jul 27 Jul 30 low €249 · high €339

Departure-day prices · December 2026 Panama City → Santo Domingo

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Cheapest days highlighted · darker = pricier · past days greyed out · cached one-way fares.

Return-day prices · December 2026 Santo Domingo → Panama City

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Best time to visit Santo Domingo — climate

Jan: ~28°C daytime, 10 rainy days 28° JanFeb: ~29°C daytime, 12 rainy days 29° FebMar: ~29°C daytime, 18 rainy days 29° MarApr: ~29°C daytime, 19 rainy days 29° AprMay: ~30°C daytime, 21 rainy days 30° MayJun: ~30°C daytime, 25 rainy days 30° JunJul: ~31°C daytime, 27 rainy days 31° JulAug: ~31°C daytime, 24 rainy days 31° AugSep: ~31°C daytime, 22 rainy days 31° SepOct: ~30°C daytime, 22 rainy days 30° OctNov: ~29°C daytime, 16 rainy days 29° NovDec: ~29°C daytime, 11 rainy days 29° Dec

Best value: Oct — fares from €224 and ~30°C daytime.

Flights from Panama City to Santo Domingo start around €224 (typically 1 stop). Range seen recently: €224–254, based on 3 fares found by travellers.

Fly (from €224)
4h 02mduration
€224–254recent fares
Book
Cheapest cached fares Panama City → Santo Domingo; typically 1 stop (e.g. CM). · Based on 3 fares found by travellers in the last 48h

Cheapest round trips to Santo Domingo

Fares found by travellers in the last 48 hours — refreshed daily.

Dec 19 – Jan 23 Copa Airlines · Direct · 2h 29m €487 Book
Sep 4 – Sep 8 avianca airlines · 2 stops · 8h 29m €497 Book
Sep 28 – Oct 4 avianca airlines · 1 stop · 4h 10m €519 Book
Sep 8 – Sep 14 avianca airlines · 1 stop · 4h 15m €528 Book

Weather in Santo Domingo

Thu ⛈️ 32° 26° 💧57%
Fri ⛈️ 32° 25° 💧98%
Sat ⛈️ 31° 24° 💧50%
Sun ⛈️ 30° 24° 💧90%
Mon ⛈️ 30° 24° 💧87%
Tue 🌦️ 31° 24° 💧54%
Wed 🌦️ 30° 25° 💧79%

In Dec, Santo Domingo typically sees ~29°C daytime highs and 11 rainy days.

Where to stay in Santo Domingo

3★+ hotels from €19/night (37 hotels sampled, ~3 weeks out).

Hotel Maison Gautreaux hotel · Santo Domingo
from €19/night★ 3
Hotel Santander SD hotel · Santo Domingo
from €23/night★ 3
Ramada Santo Domingo Princess Hotel hotel · Santo Domingo
from €38/night★ 3

Good to know

Time difference+1h
Time in the air2h 29m

Things to do in Santo Domingo

Top-rated tours and tickets from €40 — book ahead for the popular ones.

Tours and tickets provided by Viator (a Tripadvisor company). Some links earn Stayonomy a commission.

About Santo Domingo

Santo Domingo is the capital of the Dominican Republic, the oldest European city in the Americas, and the most developed city on the island of Hispaniola. The old city is on the UNESCO World Heritage List. Elsewhere in the Dominican Republic, which is named after Santo Domingo, it's more common to just call this city "the capital" than to call it by its name.

Read the full Santo Domingo guide

Guide content from Wikivoyage contributors (CC BY-SA).

Round out the trip

Popular from Panama City

Cheapest destinations travellers searched recently — refreshed daily.

Flight prices are real fares travellers found in the last 48 hours, refreshed daily — the booking site confirms the final price. Train, bus and ferry fares are shown on the operators' booking sites. Weather data by Open-Meteo; exchange rates: ECB reference. Data updated 2026-07-30. Some links earn Stayonomy a commission at no cost to you.