Santo Domingo to Guayaquil

1 ways to travelfastest 4h 25mfly from €173
Photo: Andres Medina / Unsplash

Departure-day prices · June 2026 Santo Domingo → Guayaquil

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Return-day prices · June 2026 Guayaquil → Santo Domingo

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Best time to visit Guayaquil — climate

Jan: ~31°C daytime, 12 rainy days 31° JanFeb: ~31°C daytime, 25 rainy days 31° FebMar: ~31°C daytime, 29 rainy days 31° MarApr: ~31°C daytime, 23 rainy days 31° AprMay: ~30°C daytime, 9 rainy days 30° MayJun: ~30°C daytime, 2 rainy days 30° JunJul: ~31°C daytime, 1 rainy days 31° JulAug: ~32°C daytime, 0 rainy days 32° AugSep: ~32°C daytime, 0 rainy days 32° SepOct: ~30°C daytime, 8 rainy days 30° OctNov: ~31°C daytime, 10 rainy days 31° NovDec: ~33°C daytime, 0 rainy days 33° Dec

Best value: Sep — fares from €173 and ~32°C daytime.

Flights from Santo Domingo to Guayaquil start around €173 (typically 1 stop). Range seen recently: €173–206, based on 2 fares found by travellers.

Fly (from €173)
4h 25mduration
€173–206recent fares
Book
Cheapest cached fares Santo Domingo → Guayaquil; typically 1 stop (e.g. AV). · Based on 2 fares found by travellers in the last 48h

Weather in Guayaquil

Tue 🌦️ 34° 24° 💧43%
Wed ☁️ 34° 24° 💧10%
Thu ☁️ 33° 24° 💧37%
Fri ☁️ 33° 24° 💧51%
Sat ☁️ 33° 24° 💧29%
Sun 🌦️ 36° 24° 💧30%
Mon ☁️ 33° 24° 💧27%

In Jun, Guayaquil typically sees ~30°C daytime highs and 2 rainy days.

Where to stay in Guayaquil

3★+ hotels from €23/night (25 hotels sampled, ~3 weeks out).

Hotel Malecon Inn hotel · Guayaquil
from €23/night★ 3
GH Alexander Hotel hotel · Guayaquil
from €25/night★ 3
MundialCity Hotel Guayaquil hotel · Guayaquil
from €39/night★ 3

Good to know

Time difference-1h

Things to do in Guayaquil

Top-rated tours and tickets from €102 — book ahead for the popular ones.

Tours and tickets provided by Viator (a Tripadvisor company). Some links earn Stayonomy a commission.

About Guayaquil

Guayaquil is the largest city in Ecuador. This article also covers Durán, which is a UNESCO Creative City on the other side of the river.

Read the full Guayaquil guide

Guide content from Wikivoyage contributors (CC BY-SA).

Round out the trip

Popular from Santo Domingo

Cheapest destinations travellers searched recently — refreshed daily.

Flight prices are real fares travellers found in the last 48 hours, refreshed daily — the booking site confirms the final price. Train, bus and ferry fares are shown on the operators' booking sites. Weather data by Open-Meteo; exchange rates: ECB reference. Data updated 2026-08-04. Some links earn Stayonomy a commission at no cost to you.